At University of Cornell, biomedical engineers have made possible proposing new therapies for the Alzheimer’s by discovering the culprit behind blood flow’s decreases in people’s brain having Alzheimer’s. Many of us might felt that dizzy feeling after lying on the bed for an extended period, which is probably caused due to a sudden reduction of blood flow, about thirty percent in the brain. Just like that, people having Alzheimer’s has known this feeling for years of having the presence of cerebral blood flow decrease, but it is less understood by the exact association to reduced cognitive function.
Chris Schaffer, an associate professor from the Cornell University said that, individuals start excepting to the reduced blood flow, consequently that they do not sense dizziness most of the time, nonetheless there is a clear sign that cognitive function is obstructed by it. According to a new study, an explanation for this dramatic decrease of blood flow has been offered by them. It is due to the white blood cells stuck to the inside of the smallest blood vessels in the human brain known as capillaries. Even though a minor portion of this capillaries experience this obstruction, blood flow has been decreased by every delayed vessel in numerous downstream vessels, impacting overall blood flow in the human brain.
The blood flow in the brain deficits are actually the initial symptoms that are detected at the time of Dementia, suggests a recent study. Schaffer said that, specifically, what has done is the cellular mechanism is being identified, which causes the neutrophils stabbing in capillaries, reduction of blood flow in models of Alzheimer’s. he also added that, he is super optimistic regarding this study, if it is applied in mice just as same it has played in human beings, then this mechanism of capillary blocking will be a total game changer for patients suffering the disease of Alzheimer’s.